Synonyms: Example 39 [WO2017175147A1]
Compound class:
Synthetic organic
Comment: DiABZI-4 is a non-dinucleotide STING agonist [2]. It has been shown to protect against SARS-CoV-2 infection in cells and in vivo in the K18-ACE2-transgenic mouse infection model. The compound is active via intranasal delivery. Its chemical structure is claimed in the same GSK patent as STING agonist 3 (diABZI STING agonist-1) [1].
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References |
1. Charnley AK, Darcy MG, Dodson JW, Dong X, Hughes TV, Kang J, Leister LK, Lian Y, Li Y, Mehlmann JF et al.. (2017)
Heterocyclic amides useful as protein modulators. Patent number: WO2017175147A1. Assignee: Glaxosmithkline Intellectual Property Development Limited. Priority date: 07/04/2016. Publication date: 12/10/2017. |
2. Humphries F, Shmuel-Galia L, Jiang Z, Wilson R, Landis P, Ng S-L, Parsi K-M, Maehr R, Cruz J, Morales-Ramos A et al.. (2021)
A diamidobenzimidazole STING agonist protects against SARS-CoV-2 infection. Sci Immunol, 6 (59). DOI: 10.1126/sciimmunol.abi9002 [PMID:34010139] |