Compound class:
Synthetic organic
Comment: Compound 24 is the lead identified in a medicinal chemistry study of the 6-Chloro-2-arylvinylquinolines, a novel class of small molecules with promising antimalarial activity [1].
The Malaria tab on this ligand page provides additional curator comments of relevance to the Guide to MALARIA PHARMACOLOGY. |
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References |
1. Huang G, Murillo Solano C, Melendez J, Shaw J, Collins J, Banks R, Arshadi AK, Boonhok R, Min H, Miao J et al.. (2020)
Synthesis, Structure-Activity Relationship, and Antimalarial Efficacy of 6-Chloro-2-arylvinylquinolines. J Med Chem, 63 (20): 11756-11785. [PMID:32959656] |