Synonyms: CPI-444 | CPI444 | V-81444 | V81444
Compound class:
Synthetic organic
Comment: Ciforadenant (CPI-444) is an orally active adenosine A2A receptor antagonist.
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References |
1. Leone RD, Sun IM, Oh MH, Sun IH, Wen J, Englert J, Powell JD. (2018)
Inhibition of the adenosine A2a receptor modulates expression of T cell coinhibitory receptors and improves effector function for enhanced checkpoint blockade and ACT in murine cancer models. Cancer Immunol Immunother, 67 (8): 1271-1284. [PMID:29923026] |
2. Willingham SB, Ho PY, Hotson A, Hill C, Piccione EC, Hsieh J, Liu L, Buggy JJ, McCaffery I, Miller RA. (2018)
A2AR Antagonism with CPI-444 Induces Antitumor Responses and Augments Efficacy to Anti-PD-(L)1 and Anti-CTLA-4 in Preclinical Models. Cancer Immunol Res, 6 (10): 1136-1149. [PMID:30131376] |