CXCL5   Click here for help

GtoPdb Ligand ID: 829

Synonyms: ENA-78
Immunopharmacology Ligand
Compound class: Endogenous peptide in human, mouse or rat
Comment: Bioactive CXCL5 is 78 aa in length, cleaved form a 114 aa presursor peptide. It can be N-terminally cleaved by cathepsin G and chymotrypsin to CXCL5-74 and CXCL5-70.
Species: Human
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
Immunopharmacology Comments
CXCL5 is upregulated at sites of inflammation. It is expressed by multiple hematopoietic cell types and by non-immune cells (e.g. fibroblasts, endothelial cells, vascular smooth muscle cells, and adipocytes). CXCL5 is a chemoattractant for neutrophils, as well as being involved in neutrophil homeostasis, and it exhibits angiogenic properties. The cognate receptor for CXCL5 is CXCR2.