CXCL2   Click here for help

GtoPdb Ligand ID: 827

Synonyms: GROβ | MIP-2α
Immunopharmacology Ligand
Compound class: Endogenous peptide in human, mouse or rat
Comment: CXCL2 is a C-X-C motif chemokine. It is 90% homologous to CXCL1.
Species: Human
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
Immunopharmacology Comments
CXCL2 is a lignd for the chemokine receptor CXCR2. It is expressed by monocytes and macrophages and is a chemotactic for polymorphonuclear leukocytes and hematopoietic stem cells. The ctytokine IL-17 which is required to fight infection and is an important medaitor of chronic inflammation in autoimmune diseases is able to induce CXCL2 (and CXCL1) production.