CCL8   Click here for help

GtoPdb Ligand ID: 772

Synonyms: monocyte chemotactic protein-2
Immunopharmacology Ligand
Compound class: Endogenous peptide in human, mouse or rat
Comment: CCL8 (also known as MCP-2) is a CC family chemokine.
Species: Human
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
Immunopharmacology Comments
CCL8 is a chemoattractant and activator of cells of the allergic response (mast cells, eosinophils and basophils) and the inflammatory response (monocytes, T cells, and NK cells). CCL8 can activate the chemokine receptors CCR1, CCR2B and CCR5 [1]. Binding to CCR5, a co-receptor for HIV, affords CCL8 HIV1 suppressive activity.