IL-17F

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Ligands
IL-17F (Human)

GtoPdb Ligand ID: 5873

Synonyms: cytokine ML-1 | Interleukin-17F

Compound class: Endogenous peptide in human, mouse or rat

Comment: Forms homodimeric ligand IL-17F and heterodimer IL-17A/IL-17F with IL-17A.

Species: Human

Summary
Biological activity
References
Structure
Similar ligands
Immunopharmacology

Immunopharmacology Comments
IL-17A and IL-17F are important cytokines in the host response against many extracellular pathogens, but are also recognised to cause excessive tissue damage and exacerbate proinflammatory responses during autoimmunity. A molecular mechanism underlying IL-17's role in the disease process of RA is proposed by Ganesan and Rasool (2017) [3]. The IL-17 pathway is therefore a major therapeutic target in autoimmune diseases.

Immunopharmacology Comments

IL-17A and IL-17F are important cytokines in the host response against many extracellular pathogens, but are also recognised to cause excessive tissue damage and exacerbate proinflammatory responses during autoimmunity. A molecular mechanism underlying IL-17's role in the disease process of RA is proposed by Ganesan and Rasool (2017) [3]. The IL-17 pathway is therefore a major therapeutic target in autoimmune diseases.