CXCL14

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Ligands
CXCL14 (Human)

GtoPdb Ligand ID: 3680

Synonyms: BMAC

Compound class: Endogenous peptide in human, mouse or rat

Comment: CXCL14 is a C-X-C motif chemokine with a broad spectrum of biological activities.

Species: Human

Summary
Biological activity
References
Structure
Immunopharmacology

Immunopharmacology Comments
CXCL14 participates in regulation of immune cell migration and antimicrobial immunity. Expression is inducible in monocytes, B cells, monocyte-derived immature dendritic cells and THP-1 leukemia cells. CXCL14 may play a role in immune surveillance in the skin, and have may antiangiogenic action on cancer cells. Some evidence suggests that it is an endogenous inhibitor of the CXCL12/CXCR4 signalling axis, and this effect can inhibit CXCL12-mediated chemotaxis of CD34⁺ hematopoietic progenitor cells.[2]. CXCL14 function is reviewed in [1].

Immunopharmacology Comments

CXCL14 participates in regulation of immune cell migration and antimicrobial immunity. Expression is inducible in monocytes, B cells, monocyte-derived immature dendritic cells and THP-1 leukemia cells. CXCL14 may play a role in immune surveillance in the skin, and have may antiangiogenic action on cancer cells. Some evidence suggests that it is an endogenous inhibitor of the CXCL12/CXCR4 signalling axis, and this effect can inhibit CXCL12-mediated chemotaxis of CD34⁺ hematopoietic progenitor cells.[2]. CXCL14 function is reviewed in [1].