leronlimab   Click here for help

GtoPdb Ligand ID: 10752

Synonyms: PRO 140 | PRO-140 | PRO140 | Vyrologix®
Immunopharmacology Ligand
Compound class: Antibody
Comment: Leronlimab (PRO140) is a humanized anti-CCR5 (C-C motif chemokine receptor 5) monoclonal antibody [5-6]. It was originally developed by CytoDyn as a novel strategy to manage CCR5-tropic HIV infection [4].

SARS-CoV-2 and COVID-19: Leronlimab has been administered to a number of patients with severe COVID-19, to determine its potential to reduce cytokine storm caused by this disease.
Immunopharmacology Comments
Leronlimab inhibits HIV entry into human cells but does not block RANTES signalling via the receptor [7].