compound 17l [PMID: 26288691]   Click here for help

GtoPdb Ligand ID: 10035

Immunopharmacology Ligand
Compound class: Synthetic organic
Comment: Compound 17l is a liver X receptor antagonist [1].
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 5
Topological polar surface area 55.84
Molecular weight 385.13
XLogP 4.68
No. Lipinski's rules broken 0
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Canonical SMILES COc1ccc(cc1OC)C=Cc1ccccc1N1C(=O)c2c(C1=O)cccc2
Isomeric SMILES COc1ccc(cc1OC)/C=C/c1ccccc1N1C(=O)c2c(C1=O)cccc2
InChI InChI=1S/C24H19NO4/c1-28-21-14-12-16(15-22(21)29-2)11-13-17-7-3-6-10-20(17)25-23(26)18-8-4-5-9-19(18)24(25)27/h3-15H,1-2H3/b13-11+
Immunopharmacology Comments
Compound 17l exhibits anti-inflammatory activity in vitro and represents a valuable tool for studying the anti-inflammatory effects of LXR antagonism, and the biological functions of LXR transrepression more generally [1].