vonlerolizumab   Click here for help

GtoPdb Ligand ID: 9245

Synonyms: MOXR 0916 | MOXR0916 | pogalizumab (deleted INN) | RG7888 | RO7021608
Compound class: Antibody
Comment: Vonlerolizumab (MOXR0916) was an investigational humanized anti-human OX40 monoclonal, with reported preclinical efficacy [1]. Genentech terminated their Phase 2 trial NCT03029832 and have discontinued further development.
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Summary of Clinical Use Click here for help
MOXR0916 is in early stage clinical trial in patients with solid tumours, as a monotherapy and in combination with the approved anti-PDL1 antibody atezolizumab. Click here to link to ClinicalTrials.gov's list of MOXR0916 trials.
Clinical Trials
Clinical Trial ID Title Type Source Comment References
NCT03029832 A Study of MOXR0916 in Combination With Atezolizumab Versus Atezolizumab Alone in Participants With Untreated Locally Advanced or Metastatic Urothelial Carcinoma Who Are Ineligible for Cisplatin-Based Therapy Phase 2 Interventional Genentech, Inc. A note on this clonical trial record indicates that Genentech have made the decision to discontinue clinical development of MOXR0916 for business reasons.