Xilonix TN   Click here for help

GtoPdb Ligand ID: 8528

Immunopharmacology Ligand
Compound class: Antibody
Comment: Xilonix is an investigational fully human monoclonal antibody targeting IL-1α. A patent search suggest that Xilonix is the subject of WO2009148575 [1], although we do not have access to the peptide sequences of the antibody to confirm this.
No information available.
Summary of Clinical Use Click here for help
Xilonix is being evaluated in Phase 3 clinical trial as a novel therapy for colorectal cancer, and Phase 1 for non-small cell lung cancer (NSCLC).
Mechanism Of Action and Pharmacodynamic Effects Click here for help
The rationale for using anti-IL-1α antibodies to treat cancer is provided in patent US20100040574 [2].