lurasidone   Click here for help

GtoPdb Ligand ID: 7461

Synonyms: Latuda® | SM-13496
Approved drug
lurasidone is an approved drug (FDA (2010), EMA (2014))
Compound class: Synthetic organic
Comment: Lurasidone is an atypical antipsychotic with activity at serotonin family receptors that are involved in learning and memory. It is devoid of the anticholinergic effects which are common with most other antipsychotics.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 6
Hydrogen bond donors 0
Rotatable bonds 5
Topological polar surface area 84.99
Molecular weight 492.26
XLogP 5.2
No. Lipinski's rules broken 1
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Canonical SMILES O=C1N(CC2CCCCC2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)C2C1C1CCC2C1
Isomeric SMILES O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1
InChI InChI=1S/C28H36N4O2S/c33-27-24-18-9-10-19(15-18)25(24)28(34)32(27)17-21-6-2-1-5-20(21)16-30-11-13-31(14-12-30)26-22-7-3-4-8-23(22)35-29-26/h3-4,7-8,18-21,24-25H,1-2,5-6,9-17H2/t18-,19+,20-,21-,24+,25-/m0/s1
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Summary of Clinical Use Click here for help
Approved to treat adults with schizophrenia and major depressive episodes associated with bipolar I disorder
Mechanism Of Action and Pharmacodynamic Effects Click here for help
This drug antagonises activity of the dopamine D2-like receptors and serotonin 5-HT2A and 5-HT7 receptors [1]. It also has partial agonist activity at the 5-HT1A receptor [1]. There is no measurable binding to histamine H1 and muscarinic acetylcholine receptors. The overall drug-induced effect is anxiolytic- and antidepressant-like in nature. Lurasidone activity at hippocampal 5-HT7 receptors may deliver procognitive benefits in schizophrenia patients [1].
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