dapiprazole   Click here for help

GtoPdb Ligand ID: 7155

Synonyms: AF-2139 | Rev-Eyes®
Approved drug
dapiprazole is an approved drug (FDA (1990))
Compound class: Synthetic organic
Comment: Marketed formulations may contain apiprazole hydrochloride (PubChem CID 6917787).
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 4
Hydrogen bond donors 0
Rotatable bonds 4
Topological polar surface area 37.19
Molecular weight 325.23
XLogP 4.78
No. Lipinski's rules broken 0
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Canonical SMILES Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2
Isomeric SMILES Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2
InChI InChI=1S/C19H27N5/c1-16-6-2-3-7-17(16)23-14-12-22(13-15-23)11-9-19-21-20-18-8-4-5-10-24(18)19/h2-3,6-7H,4-5,8-15H2,1H3
No information available.
Summary of Clinical Use Click here for help
Used to constrict the pupil, usually to reverse mydriasis induced for eye examination.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Dapiprazole is an antagonist of smooth muscle α-1a adrenoceptors. When applied locally to the eye, the drug causes constriction of the sphincter of the iris, reducing pupil size.