dyphylline   Click here for help

GtoPdb Ligand ID: 7070

Synonyms: Dilor®
Approved drug Immunopharmacology Ligand
dyphylline is an approved drug (FDA (1951))
Comment: Dyphylline is a bronchodilator and vasodilator.
2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 3
Topological polar surface area 102.28
Molecular weight 254.1
XLogP 0.17
No. Lipinski's rules broken 0
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Canonical SMILES OCC(Cn1cnc2c1c(=O)n(C)c(=O)n2C)O
Isomeric SMILES OCC(Cn1cnc2c1c(=O)n(C)c(=O)n2C)O
InChI InChI=1S/C10H14N4O4/c1-12-8-7(9(17)13(2)10(12)18)14(5-11-8)3-6(16)4-15/h5-6,15-16H,3-4H2,1-2H3
No information available.
Summary of Clinical Use Click here for help
Dyphylline is used to treat the symptoms of asthma, bronchitis, and emphysema.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
CHEMBL report that the molecular targets of this drug are phosphodiesterases 3A and 4 (genes PDE3A, PDE4A, PDE4B, PDE4C and PDE4D) are listed in this database, in the Cyclic nucleotide turnover section. Drug-induced inhibition of phosphodiesterases causes increased cAMP levels, which results in relaxation of the bronchial smooth muscle, and antagonises adenosine receptors. See the DrugBank link for further details.
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