telmisartan   Click here for help

GtoPdb Ligand ID: 592

Synonyms: BIBR-277SE | Kinzalmono® | Micardis® | Pritor®
Approved drug PDB Ligand
telmisartan is an approved drug (EMA & FDA (1998))
Compound class: Synthetic organic
Comment: Telmisartan is an angiotensin II (AT2) receptor antagonist drug.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 7
Topological polar surface area 72.94
Molecular weight 514.24
XLogP 7.72
No. Lipinski's rules broken 1
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Canonical SMILES CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2
Isomeric SMILES CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2
InChI InChI=1S/C33H30N4O2/c1-4-9-30-35-31-21(2)18-24(32-34-27-12-7-8-13-28(27)36(32)3)19-29(31)37(30)20-22-14-16-23(17-15-22)25-10-5-6-11-26(25)33(38)39/h5-8,10-19H,4,9,20H2,1-3H3,(H,38,39)
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Summary of Clinical Use Click here for help
Used in the treatment of hypertension and diabetic nephropathy in hypertensive patients with type 2 diabetes.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Binds reversibly and selectively to the AT1 receptor in vascular smooth muscle and adrenal gland, thus preventing the vasocontrictive effects of angiotensin II and resulting in a decrease in systematic vascular resistance.
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