insulin-like growth factor 1

Home
Ligands
insulin-like growth factor 1 (Human)

GtoPdb Ligand ID: 4971

Abbreviated name: IGF-1

Synonyms: CEP-151 | mechano growth factor (MGF) | myotrophin

insulin-like growth factor 1 is an approved drug (FDA (2005))

Compound class: Endogenous peptide in human, mouse or rat

Comment: The recombinant form of human IGF-1 is an approved drug, mecasermin.

Species: Human

View more information in the IUPHAR Pharmacology Education Project: insulin-like growth factor 1

Summary
Biological activity
Clinical data
References
Structure
Similar ligands

No information available.

No information available.

Summary of Clinical Use
In its recombinant form as the approved drug mecasermin, IGF1 is used to improve growth in pediatric patients with primary insulin-like growth factor 1 deficiency.

Summary of Clinical Use

In its recombinant form as the approved drug mecasermin, IGF1 is used to improve growth in pediatric patients with primary insulin-like growth factor 1 deficiency.

Mechanism Of Action and Pharmacodynamic Effects
Mecasermin acts through the type 1 IGF-1 receptor and mimics the effects of endogenous IGF-1 on the growth of bones and muscles.

Mechanism Of Action and Pharmacodynamic Effects

Mecasermin acts through the type 1 IGF-1 receptor and mimics the effects of endogenous IGF-1 on the growth of bones and muscles.