peptide YY   Click here for help

GtoPdb Ligand ID: 1514

Abbreviated name: PYY
Synonyms: peptide tyrosine tyrosine
Compound class: Endogenous peptide in human, mouse or rat
Comment: Peptide YY is a neuropeptide Y2 receptor agonist. It has been investigated as a potential appetite suppressant [2,6,8-9].
Species: Human
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View more information in the IUPHAR Pharmacology Education Project: peptide yy

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Summary of Clinical Use Click here for help
The anorexic effect of peptide YY(3-36) in overweight patients has been evaluated in early stage clinical trial (for example see NCT00331175). It is likely that the clinical effect of PYY(3-36) was limited by rapid metabolic conversion to the inactive (3-34) peptide [10].
Clinical Trials
Clinical Trial ID Title Type Source Comment References
NCT00331175 Safety, Toleration and Pharmacokinetics of Single Intravenous Doses of Peptide YY in Overweight Adults Phase 1 Interventional Pfizer