Synonyms: 1-methylmethylergonovine | Deseril® | Sansert® | UML-491
methysergide is an approved drug (FDA (1962))
Compound class:
Synthetic organic
Comment: Methysergide is an ergot alkaloid. When used, this drug is administered as methysergide maleate (PubChem CID 5281073). The use of ergot alkaloids has been discontinued or restricted due to their propensity to cause fibrosis.
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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No information available. |
Summary of Clinical Use |
Used in the treatment of migraine and cluster headaches. Use of this drug is discontinued in the US. |
Mechanism Of Action and Pharmacodynamic Effects |
Serotonin receptor antagonist acting on the central nervous system leading to smooth muscle constriction. |