LH   Click here for help

GtoPdb Ligand ID: 1159

Synonyms: luteinising hormone | luteinizing hormone
Approved drug
LH is an approved drug (FDA (2004))
Compound class: Endogenous peptide in human, mouse or rat
Comment: The approved drug lutropin alfa (INN) is the recombinant form of human LH and is composed of two subunits (α = 92 amino acids, β = 121 amino acids).
Species: Human
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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Summary of Clinical Use Click here for help
Used for female fertility treatment, fulfilling the same actions as endogenous pituitary luteinizing hormone. Normally used in combination with follicle stimulating hormone.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Binding to the LH receptor signals through the adenylate cylcase pathway leading to increased steroid hormone production and follicle maturation.