litifilimab   Click here for help

GtoPdb Ligand ID: 11122

Synonyms: BIIB-059 | BIIB059
Immunopharmacology Ligand
Compound class: Antibody
Comment: Litifilimab (BIIB059) is a fully humanized IgG1, CLEC4C (blood dendritic cell antigen 2, BDCA2) targeting monoclonal antibody. It is being evaluated for ability to reduce release of disease-driving interferons (principally IFN-α) in SLE/CLE. BIIB059 was developed by Biogen, based on prior evidence of target engagement and SLE-applicable immunomodulatory efficacy of a humanized mAb against BDCA2 named 24F4A [3].
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Summary of Clinical Use Click here for help
BIIB059 has progressed to Phase 2 clinical evaluation as a monotherapy in patients with SLE and active CLE.
Clinical Trials
Clinical Trial ID Title Type Source Comment References
NCT03224793 Safety, Tolerability, and Pharmacokinetics of Single Doses of BIIB059 in Healthy Japanese Subjects. Phase 1 Interventional Biogen
NCT02106897 Study Evaluating the Safety, Tolerability, and Pharmacokinetics of Single Doses and Multiple Doses of BIIB059 in Healthy Volunteers and Participants With Systemic Lupus Erythematosus Phase 1 Interventional Biogen This study is known as the 'LILAC' trial. Results suggest that targeting pDCs has efficacy in patients with SLE, especially in patients with cutaneous manifestations for whom it reduced skin lesions. 1
NCT02847598 Study to Evaluate BIIB059 in Cutaneous Lupus Erythematosus (CLE) With or Without Systemic Lupus Erythematosus (SLE) Phase 2 Interventional Biogen Compared to placebo and pre-treatment disease scores, litifilimab treatment was associated with decreased skin disease activity in CLE, and a reduction in the number of swollen and tender joints in SLE. 2,4