Unknown MOA
|
|
|
|
Parasite liver stage assay |
- |
- |
8.7 |
pIC50 |
- |
1 |
|
⤷ |
pIC50
8.7
(IC50 2x10-9 M)
Sporozoite hepatocyte invasion assay
[1]
Lifecycle stages: Plasmodium liver stage (sporozoite, hepatic schizont, hepatic merozoite)
|
Unknown MOA
|
|
|
|
Parasite growth inhibition assay |
- |
- |
8.2 |
pIC50 |
- |
1 |
|
⤷ |
pIC50
8.2
(IC50 6x10-9 M)
SYBR Green assay
[1]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
|
Unknown MOA
|
|
|
|
Parasite growth inhibition assay |
- |
- |
8.1 |
pIC50 |
- |
1 |
|
⤷ |
pIC50
8.1
(IC50 7.1x10-9 M)
SYBR Green assay
[1]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
|
Unknown MOA
|
|
|
|
Parasite growth inhibition assay |
- |
- |
8.1 |
pIC50 |
- |
1 |
|
⤷ |
pIC50
8.1
(IC50 7.3x10-9 M)
SYBR Green assay
[1]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
|
Unknown MOA
|
|
|
|
Parasite growth inhibition assay |
- |
- |
8.1 |
pIC50 |
- |
1 |
|
⤷ |
pIC50
8.1
(IC50 7.7x10-9 M)
SYBR Green assay
[1]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
|
Unknown MOA
|
|
|
|
Parasite growth inhibition assay |
- |
- |
8.1 |
pIC50 |
- |
1 |
|
⤷ |
pIC50
8.1
(IC50 8.4x10-9 M)
SYBR Green assay
[1]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
|
Unknown MOA
|
|
|
|
Parasite growth inhibition assay |
- |
- |
8.1 |
pIC50 |
- |
1 |
|
⤷ |
pIC50
8.1
(IC50 9x10-9 M)
SYBR Green assay
[1]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
|
Unknown MOA
|
|
|
|
Parasite growth inhibition assay |
- |
- |
8.0 |
pIC50 |
- |
1 |
|
⤷ |
pIC50
8.0
(IC50 1.02x10-8 M)
SYBR Green assay
[1]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
|
Unknown MOA
|
|
|
|
Parasite growth inhibition assay |
- |
- |
7.9 |
pIC50 |
- |
1 |
|
⤷ |
pIC50
7.9
(IC50 1.14x10-8 M)
SYBR Green assay
[1]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
|
Unknown MOA
|
|
|
|
Parasite growth inhibition assay |
- |
- |
7.8 |
pIC50 |
- |
1 |
|
⤷ |
pIC50
7.8
(IC50 1.64x10-8 M)
SYBR Green assay
[1]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
|
Unknown MOA
|
|
|
|
Parasite growth inhibition assay |
- |
- |
7.8 |
pIC50 |
- |
1 |
|
⤷ |
pIC50
7.8
(IC50 1.66x10-8 M)
SYBR Green assay
[1]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
|
Unknown MOA
|
|
|
|
Parasite gametocyte maturation assay |
- |
- |
- |
- |
- |
1 |
|
⤷ |
Giemsa-stained blood film counts: potent inhibiton of gametocyte maturation at concentrations as low as 50 nM
[1]
Lifecycle stages: Plasmodium sexual blood stage (gametocyte)
|
Unknown MOA
|
|
|
|
Standard membrane feeding assay (SMFA) |
- |
- |
- |
- |
- |
1 |
|
⤷ |
Oocyst count: >90% reduction of oocyst numbers at a concentration of 500 nM
[1]
Lifecycle stages: Plasmodium mosquito host stage (gametocyte, gamete, zygote, ookinete, oocyst, sporozoite)
|