Compound class:
Endogenous peptide in human, mouse or rat
Comment: Semaphorin 3A is a secreted class 3 semaphorin. It is a ligand for neuropilin 1. SEMA3A has an immunoglobulin-like, C2-type domain, a PSI domain and a Sema domain. This peptide is critical for normal neuronal pattern development. Increased SEMA3A expression is reported on some tumour cells [1].
Species: Human
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Bioactivity Comments |
A loss-of-function mutation in SEMA3A has been identified in a patient with Kallmann syndrome (pubertal failure with congenitally absent or impaired sense of smell) [3]. Note that mice lacking Sema3a expression exhibit a Kallmann-like phenotype. |
Natural/Endogenous Targets | ||
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