CZ415   Click here for help

GtoPdb Ligand ID: 9837

Synonyms: compound 3 [PMID: 27563401] | CZ-415
Immunopharmacology Ligand
Compound class: Synthetic organic
Comment: CZ415 is a potent and selective, ATP-competitive mTOR inhibitor that has potential anti-inflammatory activity [1].
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 7
Hydrogen bond donors 2
Rotatable bonds 6
Topological polar surface area 87.76
Molecular weight 455.24
XLogP 3.52
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES CCNC(=O)Nc1ccc(cc1)c1nc(N2CCOCC2C)c2c(n1)C(C)(C)S(=C)(=C)C2
Isomeric SMILES CCNC(=O)Nc1ccc(cc1)c1nc(N2CCOC[C@@H]2C)c2c(n1)C(C)(C)S(=C)(=C)C2
InChI InChI=1S/C24H33N5O2S/c1-7-25-23(30)26-18-10-8-17(9-11-18)21-27-20-19(15-32(5,6)24(20,3)4)22(28-21)29-12-13-31-14-16(29)2/h8-11,16H,5-7,12-15H2,1-4H3,(H2,25,26,30)/t16-/m0/s1
InChI Key AQEVFCKBHLCDIP-INIZCTEOSA-N
Bioactivity Comments
CZ415 is >1000-fold selective for mTOR over other lipid kinases from the same family (i.e. phosphatidylinositide 3-kinases (PI3K) α/&beta/γ/δ and DNA-dependent protein kinase (DNAPK)) [1]. CZ415 inhibits mTORC1- and mTORC2-dependent signalling in vitro (assessed as inhibition of phosphorylation of the downstream targets S6 ribosomal protein and protein kinase B respectively) with high potency. As a therapeutic lead, CZ415 has low hERG liability (IC50 48μM).
Selectivity at enzymes
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
mechanistic target of rapamycin kinase Primary target of this compound Hs Inhibitor Inhibition 8.1 pIC50 - 1
⤷ pIC50 8.1 (IC50 8.51x10-9 M) [1]
Description: Assessed in a competition binding assay using a mixed inhibitor lipid kinase matrix.