AZD1678   Click here for help

GtoPdb Ligand ID: 9679

Synonyms: AZD-1678 | compound 49 [PMID: 28947948]
Immunopharmacology Ligand
Compound class: Synthetic organic
Comment: AZD1678 is a potent and bioavailable aminopyrazine sulfonamide CCR4 receptor antagonist discovered in a high-throughput screening/synthesis campaign [1]
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 4
Topological polar surface area 89.56
Molecular weight 350.96
XLogP 3.08
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES COc1nc(F)cnc1NS(=O)(=O)c1cccc(c1Cl)Cl
Isomeric SMILES COc1nc(F)cnc1NS(=O)(=O)c1cccc(c1Cl)Cl
InChI InChI=1S/C11H8Cl2FN3O3S/c1-20-11-10(15-5-8(14)16-11)17-21(18,19)7-4-2-3-6(12)9(7)13/h2-5H,1H3,(H,15,17)
InChI Key NWSUDJQTTGDPIR-UHFFFAOYSA-N
Bioactivity Comments
AZD1678 inhibits CCR4-mediated chemotaxis in response to the endogenous CCR4 agonists CCL22 and CCL17. AZD1678 is devoid of agonist activity up to a concentration of 10 μM [1].
Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
CCR4 Mm Antagonist Antagonist 9.0 pIC50 - 1
⤷ pIC50 9.0 (IC50 1x10-9 M) [1]
CCR4 Rn Antagonist Antagonist 9.0 pIC50 - 1
⤷ pIC50 9.0 (IC50 1x10-9 M) [1]
CCR4 Hs Antagonist Antagonist 8.6 pIC50 - 1
⤷ pIC50 8.6 (IC50 2.5x10-9 M) [1]
CCR4 Clf Antagonist Antagonist 8.5 pIC50 - 1
⤷ pIC50 8.5 (IC50 3.16x10-9 M) [1]