adropin   Click here for help

GtoPdb Ligand ID: 9573

Comment: Adropin is a peptide hormone translated form he EHNO gene [2]. Its biological function is poorly understood, but it was originally suggested to be linked to energy homeostasis and lipid metabolism [1-3].
Adropin has been suggested as an endogenous ligand for the orphan GPCR, GPR19 [4-5], although de-orphanisation requires further confirmatory evidence.
The amino acid sequence of this protein in humans, mice and rats is identical.
Species: Human
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Selectivity at GPCRs
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
GPR19 Hs Agonist Agonist 8.1 pEC50 - 4
pEC50 8.1 (EC50 7.7x10-9 M) [4]
Description: In a TGFα-shedding assay using synthetic adropin.