Bioactivity Comments

Without being able to identify the precise peptide sequences of MCS110, it is difficult to interpret which antibody disclosed in the patent is MCS110. The document discusses human engineered versions of RXI, 5H4 and MCI antibodies but it is unclear if the Kd values presented in Table 8 refer to these or their murine counterparts [1]. Although the affinities are likely to be similar. The Kd range in the interaction table is taken from Table 8.

Selectivity at ligand targets
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Target Sp. Type Action Value Parameter Concentration range (M) Reference M-CSF Hs Antibody Binding 8.5 – 9.8 pKd - 1 ⤷ pKd 8.5 – 9.8 (Kd 3x10-9 – 1.6x10-10 M) [1]