enokizumab   Click here for help

GtoPdb Ligand ID: 8934

Synonyms: 7F3com-2H2 | MEDI-528 | MEDI528
Immunopharmacology Ligand
Compound class: Antibody
Comment: Enokizumab is a humanized monoclonal antibody targeting interleukin 9 (IL-9), being investigated for its immunomodulatory potential.
Peptide sequences for this antibody are available from its IMGT/mAb-DB record.
BLAST peptide searches using the variable regions of the heavy and light chains of the antibody reveal exact matches with sequences submitted with patent US7354584 [5], which correspond to antibody construct 7F3com-2H2 therein..
Selectivity at ligand targets
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
IL-9 Primary target of this compound Hs Antibody Binding 11.2 pKd - 5
⤷ pKd 11.2 (Kd 6x10-12 M) [5]