milatuzumab   Click here for help

GtoPdb Ligand ID: 8267

Synonyms: hLL1 | IMMU-115
Immunopharmacology Ligand
Compound class: Antibody
Comment: Milatuzumab is a humanized monoclonal antibody targeting CD74, a cell surface molecule which links the innate and adaptive immune responses by regulating the survival of macrophages and B cells. CD74 is also known as the invariant chain of major histocompatibility complex class II and acts as a receptor for macrophage migration inhibitory factor (MIF).
Milatuzumab may also be conjugated with doxorubicin creating the antibody-drug conjugate (ADC) hLL1-DOX (aka IMMU-110) [1].
Peptide sequence information for this antibody is available from its IMGT/mAb-DB link.
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Selectivity at other protein targets
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
CD74 Primary target of this compound Hs Antibody Binding 9.3 pKd - 1
pKd 9.3 (Kd 5x10-10 M) [1]