CCL19   Click here for help

GtoPdb Ligand ID: 810

Synonyms: β-chemokine exodus-3 | ck β-11 | ckβ11 | MIP-3β
Immunopharmacology Ligand
Compound class: Endogenous peptide in human, mouse or rat
Comment: CCL19 is a CC family chemokine.
Species: Human
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
Bioactivity Comments
The receptor for CCL19 is CCR7. CCL19 is maily expressed in thymus and lymph nodes, and functions in trafficking of T cells in the thymus and migration of T and B cells to secondary lymphoid organs.
Natural/Endogenous Targets
Target
ACKR4
CCR7
CCRL2
CXCR3
Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
CCR7 Ligand is endogenous in the given species Hs Agonist Agonist 10.0 pKd - 4
⤷ pKd 10.0 (Kd 1x10-10 M) [4]
ACKR4 Ligand is endogenous in the given species Hs Agonist Agonist 8.4 pKi - 5
⤷ pKi 8.4 [5]
CXCR3 Ligand is endogenous in the given species Hs Agonist Full agonist 5.9 pKi - 6
⤷ pKi 5.9 [6]
ACKR4 Ligand is endogenous in the given species Hs Agonist Agonist 8.5 – 9.1 pEC50 - 5
⤷ pEC50 8.5 – 9.1 [5]
CCR7 Ligand is endogenous in the given species Hs Agonist Agonist 7.7 – 9.0 pIC50 - 3,7-8
⤷ pIC50 7.7 – 9.0 [3,7-8]
CCRL2 Ligand is endogenous in the given species Hs Agonist Unknown 7.4 pIC50 - 2
⤷ pIC50 7.4 [2]
Additional information and targets (data relate to human unless otherwise stated)
Description Data Reference
Endogenous ligands at CCRL2 chemerin C-terminal peptide, CCL19 (CCL19, Q99731) 1