secukinumab   Click here for help

GtoPdb Ligand ID: 8078

Synonyms: AIN 457 | AIN457 | Cosentyx® | NVP-AIN457
Approved drug Immunopharmacology Ligand
secukinumab is an approved drug (Japan (2014), FDA and EMA (2015))
Compound class: Antibody
Comment: Peptide sequences for this antibody are available from its IMGT/mAb-DB entry.
This antibody is the subject of patent US7807155 [2].
Selectivity at ligand targets
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
IL-17A Primary target of this compound Hs Antibody Binding 9.9 pKd - 2
⤷ pKd 9.9 (Kd 1.22x10-10 M) [2]
Description: Binding affinity for recombinant human IL-17
IL-17A Primary target of this compound Hs Antibody Binding 8.7 pIC50 - 2
⤷ pIC50 8.7 (IC50 2.1x10-9 M) [2]
Description: Inhibition of IL-17-induced IL-6 production by human dermal fibroblasts.