Ligand id: 7685

Name: mepolizumab

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View more information in the IUPHAR Pharmacology Education Project: mepolizumab

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
In monkey studies mepolizumab decreased eosinophil count with an IC50 of 1.43 μg/ml, and exhibited a half-life of ~14.5 days [9].
Selectivity at ligand targets
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
IL-5 Hs Antibody Binding 11.4 pKd - 5
pKd 11.4 (Kd 4.2x10-12 M) [5]
Description: Binding affinity for recombinant human IL-5.