CCL5   Click here for help

GtoPdb Ligand ID: 758

Synonyms: eosinophil chemotactic cytokine [EoCP] | regulated upon activation normal T cell expressed and secreted (RANTES)
Immunopharmacology Ligand
Comment: CCL5 (also known as RANTES- an acronym for regulated on activation, normal T cell expressed and secreted) is a CC family chemokine, that has HIV suppressive activity, as do the related CD8+ T cell chemokines CCL3 and CCL4.
Species: Human
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Natural/Endogenous Targets
Target
CCR1
CCR3
CCR5
CXCR3
GPR75
Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
CCR5 Ligand is endogenous in the given species Hs Agonist Full agonist 9.2 – 9.7 pKi - 1,7-8
pKi 9.2 – 9.7 [1,7-8]
CCR3 Ligand is endogenous in the given species Hs Agonist Full agonist 8.5 – 9.3 pKi - 3
pKi 8.5 – 9.3 [3]
CCR1 Ligand is endogenous in the given species Hs Agonist Full agonist 6.8 – 8.2 pKi - 2,4
pKi 6.8 – 8.2 [2,4]
CXCR3 Ligand is endogenous in the given species Hs Agonist Full agonist 6.4 pKi - 11
pKi 6.4 [11]
GPR75 Ligand is endogenous in the given species Hs Agonist Full agonist 9.6 pEC50 - 5
pEC50 9.6 (EC50 2.6x10-10 M) [5]
Additional information and targets (data relate to human unless otherwise stated)
Description Data Reference
Targets where the ligand is described in the comment field
Target Comment