brodalumab   Click here for help

GtoPdb Ligand ID: 7540

Synonyms: AMG-827 | AMG827 | Kyntheum® | Lumicef® | Siliq®
Approved drug Immunopharmacology Ligand
brodalumab is an approved drug (Japan (2016), FDA (2017), EMA (2017))
Compound class: Antibody
Comment: Brodalumab is a human monoclonal antibody designed for the treatment of inflammatory diseases. It targets the interleukin 17 receptor A (IL17RA).
Annotated peptide sequences for this antibody are available from its IMGT/mAb-DB record.
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Bioactivity Comments
BLAST searches using the peptide sequences of the heavy and light chains of brodalumab link to patent US7767206 [7], and monoclonal antibody clone AMH14/AML14.
Selectivity at catalytic receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
Interleukin 17 receptor A Primary target of this compound Hs Antibody Binding 9.2 pKd - 7
pKd 9.2 (Kd 6.9x10-10 M) [7]