Bioactivity Comments

The inhibitory effects gevokizumab of arise from a classic allosteric ternary complex mechanism whereby the antibody binds to the orthosteric agonist IL-1β, modulating the interaction with the orthosteric site on the receptor [3,6]. Sequence analysis of the peptide sequence of gevokizumab indicate a match for sequence ID 15 from patent US7531166 [4], suggesting that gevokizumab derives from clone AB7. Data for clone AB7 is included in the interaction table below.

Selectivity at ligand targets
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Target Sp. Type Action Value Parameter Concentration range (M) Reference IL-1β Hs Antibody Binding 12.5 pKd - 3-4 ⤷ pKd 12.5 (Kd 3x10-13 M) [3-4]