ramucirumab   Click here for help

GtoPdb Ligand ID: 7390

Synonyms: Cyramza® | IMC-1121B
Approved drug
ramucirumab is an approved drug (FDA & EMA (2014))
Compound class: Antibody
Comment: Ramucirumab is an anti-VEGF2 receptor (KDR) monoclonal antibody that is used in oncology.

Peptide sequences and structural information for ramucirumab are available from its IMGT/mAb-DB record.
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
Selectivity at catalytic receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
kinase insert domain receptor Primary target of this compound Hs Antibody Antagonist 10.3 pKd - 2
⤷ pKd 10.3 (Kd 5x10-11 M) [2]
kinase insert domain receptor Primary target of this compound Hs Antibody Antagonist 9.0 pIC50 - 2
⤷ pIC50 9.0 (IC50 1x10-9 M) [2]