C646   Click here for help

GtoPdb Ligand ID: 7004

Immunopharmacology Ligand
Compound class: Synthetic organic
Comment: The structure represented here was drawn from [1], with our structure showing the charges on the nitro functional group. However, this molecule is drawn with one unspecified bond in [3] which matches PubChem CID 2871948.
A 2017 article by Dahlin et al. suggests that the thiol-reactivity of C464 brings in to question its activity as a selective HAT inhibitor [2], and this is somewhat confirmed by evidence of histone deacetylase inhibition reported in [4].
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 126.25
Molecular weight 445.13
XLogP 4.84
No. Lipinski's rules broken 0
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Canonical SMILES CC1=NN(C(=O)C1=Cc1ccc(o1)c1cc(C)c(cc1[N+](=O)[O-])C)c1ccc(cc1)C(=O)O
Isomeric SMILES CC1=NN(C(=O)/C/1=C\c1ccc(o1)c1cc(C)c(cc1[N+](=O)[O-])C)c1ccc(cc1)C(=O)O
InChI InChI=1S/C24H19N3O6/c1-13-10-20(21(27(31)32)11-14(13)2)22-9-8-18(33-22)12-19-15(3)25-26(23(19)28)17-6-4-16(5-7-17)24(29)30/h4-12H,1-3H3,(H,29,30)/b19-12-
Bioactivity Comments
C646 is selective for EP300, inhibiting 86% of EP300 activity, but <10% of activity of other enzymes tested; Supplementary table S2 in [1].
Selectivity at other protein targets
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
E1A binding protein p300 Hs Inhibitor Inhibition 6.4 pKi - 1
pKi 6.4 (Ki 4x10-7 M) [1]