adrenomedullin   

GtoPdb Ligand ID: 683

Abbreviated name: AM
Comment: Adrenomedullin is 52 amino acid peptide which is mainly expressed in endothelial and smooth muscle cells. It acts as a vasodilatory peptide and it is known to regulate endothelial barrier function and vascular tone. Evidence from animal models indicates that it is a key player in the development of sepsis-associated hemodynamic and microcirculatory disorders.
Species: Human
Natural/Endogenous Targets
Target
AM1 receptor
AM2 receptor
AMY1 receptor
AMY2 receptor
AMY3 receptor
CGRP receptor
CT receptor
Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
AM1 receptor Hs Agonist Full agonist 8.3 – 9.2 pKi - 1,7
pKi 8.3 – 9.2 [1,7]
AM2 receptor Hs Agonist Full agonist 8.3 – 9.0 pKi - 1-2
pKi 8.3 – 9.0 [1-2]
CGRP receptor Hs Agonist Full agonist 8.1 pKi - 1,7
pKi 8.1 [1,7]
AMY2 receptor Hs Agonist Full agonist 9.2 pEC50 - 6
pEC50 9.2 [6]
AMY3 receptor Hs Agonist Full agonist 6.9 – 8.3 pEC50 - 5-6
pEC50 6.9 – 8.3 [5-6]
AMY1 receptor Hs Agonist Full agonist 6.5 – 8.4 pEC50 - 5-6
pEC50 6.5 – 8.4 [5-6]
CT receptor Hs Agonist Full agonist 6.7 – 7.7 pEC50 - 5-6
pEC50 6.7 – 7.7 [5-6]
Additional information and targets (data relate to human unless otherwise stated)
Description Data Reference
Ligand mentioned in the following text fields