von Willebrand factor   Click here for help

GtoPdb Ligand ID: 6755

Synonyms: Vonvendi® | vWF
Approved drug
von Willebrand factor is an approved drug (FDA (2015))
Compound class: Endogenous peptide in human, mouse or rat
Comment: Details of the structure of von Willebrand factor (vWF) are available in its UniProt record. The pre-pro peptide is 2813 amino acids, with residues 1-22 being the signal peptide, residues 23-763 forming von Willebrand antigen 2, and the remaining 2050 residues (764-2813) constituting vWF. The Uniprot record also provides details of mutations underlying defective vWF activity in the three subtypes of von Willebrand disease.
Species: Human
Additional information and targets (data relate to human unless otherwise stated)
Description Data Reference
Ligands at integrin αIIbβ3 fibrinogen (FGA, FGB, FGG, P02671, P02675, P02679), fibronectin (FN1, P02751), von Willebrand factor (VWF, P04275), vitronectin (VTN, P04004), thrombospondin
Ligands at integrin αVβ3 vitronectin (VTN, P04004), fibronectin (FN1, P02751), fibrinogen (FGA, FGB, FGG, P02671, P02675, P02679), osteopontin (SPP1, P10451), von Willebrand factor (VWF, P04275), thrombospondin, tenascin
Other ligands which bind to or alter the activity of this ligand
Key to terms and symbols Click column headers to sort
Ligand Sp. Type Action Value Parameter Concentration range (M) Reference
caplacizumab Peptide Approved drug Primary target of this compound Hs Antibody Binding 8.5 pKd - 1
⤷ pKd 8.5 (Kd 3.1x10-9 M) [1]
Ligand mentioned in the following text fields
Integrins comments