cholic acid   

GtoPdb Ligand ID: 609

Abbreviated name: CA
Synonyms: cholate | Cholbam® | Kolbam® | Orphacol&Reg;
cholic acid is an approved drug (EMA (2013), FDA (2015))
Comment: Cholic acid is a primary bile acid. Along with chenodeoxycholic acid, it is one of the two major bile acids synthesized from cholesterol in the liver.
2D Structure
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Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 4
Rotatable bonds 4
Topological polar surface area 97.99
Molecular weight 408.29
XLogP 4.09
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
Canonical SMILES OC1CCC2(C(C1)CC(C1C2CC(O)C2(C1CCC2C(CCC(=O)O)C)C)O)C
Isomeric SMILES O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C
InChI InChI=1S/C24H40O5/c1-13(4-7-21(28)29)16-5-6-17-22-18(12-20(27)24(16,17)3)23(2)9-8-15(25)10-14(23)11-19(22)26/h13-20,22,25-27H,4-12H2,1-3H3,(H,28,29)/t13-,14+,15-,16-,17+,18+,19-,20+,22+,23+,24-/m1/s1
InChI Key BHQCQFFYRZLCQQ-OELDTZBJSA-N
Natural/Endogenous Targets
Target
Farnesoid X receptor
GPBA receptor
Transporters Moving this Compound Across a Lipid Membrane
Transporter EC number Reaction Reference
Sodium/bile acid and sulphated solute cotransporter 1 4
Sodium/bile acid and sulphated solute cotransporter 2 1
Selectivity at GPCRs
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
GPBA receptor Hs Agonist Full agonist 5.0 pEC50 - 3
pEC50 5.0 [3]
Selectivity at nuclear hormone receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
Farnesoid X receptor N/A Agonist Agonist 4.0 – 5.0 pEC50 - 5-6
pEC50 4.0 – 5.0 [5-6]
Additional information and targets (data relate to human unless otherwise stated)
Description Data Reference