nintedanib   Click here for help

GtoPdb Ligand ID: 5936

Synonyms: BIBF-1120 | BIBF1120 | Ofev® | Vargatef®
Approved drug PDB Ligand
nintedanib is an approved drug (FDA & EMA (2014))
Compound class: Synthetic organic
Comment: Nintedanib is a kinase inhibitor, targeting three arms of proangiogenic signalling via VEGFRs, PDGFR and FGFR [2]. It was developed by Boehringer Ingelheim.
Marketed formulations contain nintedanib esylate (PubChem CID 135476717).
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species

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View more information in the IUPHAR Pharmacology Education Project: nintedanib

nintedanib is commercially available from our sponsors

2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 9
Hydrogen bond donors 2
Rotatable bonds 9
Topological polar surface area 94.22
Molecular weight 539.25
XLogP 3.14
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES COC(=O)c1ccc2c(c1)NC(=O)C2=C(c1ccccc1)Nc1ccc(cc1)N(C(=O)CN1CCN(CC1)C)C
Isomeric SMILES COC(=O)c1ccc2c(c1)NC(=O)/C/2=C(/c1ccccc1)\Nc1ccc(cc1)N(C(=O)CN1CCN(CC1)C)C
InChI InChI=1S/C31H33N5O4/c1-34-15-17-36(18-16-34)20-27(37)35(2)24-12-10-23(11-13-24)32-29(21-7-5-4-6-8-21)28-25-14-9-22(31(39)40-3)19-26(25)33-30(28)38/h4-14,19,32H,15-18,20H2,1-3H3,(H,33,38)/b29-28-
InChI Key XZXHXSATPCNXJR-ZIADKAODSA-N
Bioactivity Comments
Nintedanib is active in vivo, its effects observed as decreased vessel density and integrity and significant growth inhibition [2]. Nintedanib is rapidly metabolised to BIBF-1202 [5].
We have tagged FLT4 (VEGFR-3) as this drug's primary molecular target for data metrics purposes only. We fully acknowledge the multi-targeted nature of nintedanib and include reported kinase interactions in the table below.
Selectivity at enzymes
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
large tumor suppressor kinase 1 Hs Inhibitor Inhibition 5.0 pKd - 4
⤷ pKd 5.0 (Kd 1.071x10-5 M) [4]
Selectivity at catalytic receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
fms related receptor tyrosine kinase 4 Primary target of this compound Hs Inhibitor Inhibition 7.9 pIC50 - 2
⤷ pIC50 7.9 (IC50 1.3x10-8 M) [2]
kinase insert domain receptor Hs Inhibitor Inhibition 7.7 pIC50 - 2
⤷ pIC50 7.7 (IC50 2.1x10-8 M) [2]
fms related receptor tyrosine kinase 1 Hs Inhibitor Inhibition 7.5 pIC50 - 2
⤷ pIC50 7.5 (IC50 3.1x10-8 M) [2]
fibroblast growth factor receptor 2 Hs Inhibitor Inhibition 7.4 pIC50 - 2
⤷ pIC50 7.4 (IC50 3.7x10-8 M) [2]
platelet derived growth factor receptor alpha Hs Inhibitor Inhibition 7.2 pIC50 - 2
⤷ pIC50 7.2 (IC50 5.9x10-8 M) [2]
platelet derived growth factor receptor beta Hs Inhibitor Inhibition 7.2 pIC50 - 2
⤷ pIC50 7.2 (IC50 6.5x10-8 M) [2]
fibroblast growth factor receptor 1 Hs Inhibitor Inhibition 7.2 pIC50 - 2
⤷ pIC50 7.2 (IC50 6.9x10-8 M) [2]
fibroblast growth factor receptor 3 Hs Inhibitor Inhibition 7.0 pIC50 - 2
⤷ pIC50 7.0 (IC50 1.08x10-7 M) [2]
fibroblast growth factor receptor 4 Hs Inhibitor Inhibition 6.2 pIC50 - 2
⤷ pIC50 6.2 (IC50 6.1x10-7 M) [2]