C5a des-Arg   Click here for help

GtoPdb Ligand ID: 574

Synonyms: C5a des-Arg74
Comment: C5a des-Arg is a natural breakdown product of C5a via the serum enzyme carboxypeptidase B from 74 to 73 amino acids.
Species: Human
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Natural/Endogenous Targets
Target
C5a1 receptor
C5a2 receptor
Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
C5a2 receptor Ligand is endogenous in the given species Hs Agonist Full agonist 8.6 pEC50 -
pEC50 8.6 (EC50 2.3x10-9 M)
C5a2 receptor Ligand is endogenous in the given species Hs Agonist Agonist 7.4 – 7.9 pIC50 - 2,4
pIC50 7.4 – 7.9 (IC50 3.65x10-8 – 1.2x10-8 M) [2,4]
C5a1 receptor Ligand is endogenous in the given species Hs Agonist Partial agonist 6.2 – 6.4 pIC50 - 2-3
pIC50 6.2 – 6.4 [2-3]
Additional information and targets (data relate to human unless otherwise stated)
Description Data Reference
Ligand mentioned in the following text fields