sunitinib   Click here for help

GtoPdb Ligand ID: 5713

Synonyms: SU11248 | Sutent®
Approved drug PDB Ligand
sunitinib is an approved drug (FDA and EMA (2006))
Compound class: Synthetic organic
Comment: Sunitinib is a Type-1 kinase inhibitor and was first approved by the US FDA and EMA in 2006.
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species

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View more information in the IUPHAR Pharmacology Education Project: sunitinib

2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 5
Hydrogen bond donors 3
Rotatable bonds 8
Topological polar surface area 77.23
Molecular weight 398.21
XLogP 2.94
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES CCN(CCNC(=O)c1c(C)[nH]c(c1C)C=C1C(=O)Nc2c1cc(F)cc2)CC
Isomeric SMILES CCN(CCNC(=O)c1c(C)[nH]c(c1C)/C=C/1\C(=O)Nc2c1cc(F)cc2)CC
InChI InChI=1S/C22H27FN4O2/c1-5-27(6-2)10-9-24-22(29)20-13(3)19(25-14(20)4)12-17-16-11-15(23)7-8-18(16)26-21(17)28/h7-8,11-12,25H,5-6,9-10H2,1-4H3,(H,24,29)(H,26,28)/b17-12-
InChI Key WINHZLLDWRZWRT-ATVHPVEESA-N
Selectivity at enzymes
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
large tumor suppressor kinase 2 Hs Inhibitor Inhibition 6.3 pKd - 8
⤷ pKd 6.3 (Kd 4.6x10-7 M) [8]
large tumor suppressor kinase 1 Hs Inhibitor Inhibition 6.2 pKd -
⤷ pKd 6.2 (Kd 6.3x10-7 M)
Selectivity at catalytic receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
KIT proto-oncogene, receptor tyrosine kinase Primary target of this compound Hs Inhibitor Inhibition 9.4 pKd - 2
⤷ pKd 9.4 (Kd 3.7x10-10 M) [2]
platelet derived growth factor receptor beta Primary target of this compound Hs Inhibitor Inhibition 8.1 pKi - 6
⤷ pKi 8.1 (Ki 8x10-9 M) [6]
fibroblast growth factor receptor 1 Hs Inhibitor Inhibition 6.1 pKi - 6
⤷ pKi 6.1 (Ki 8.3x10-7 M) [6]
ret proto-oncogene Hs Inhibitor Inhibition 8.8 pIC50 - 5
⤷ pIC50 8.8 (IC50 1.7x10-9 M) [5]
platelet derived growth factor receptor beta Primary target of this compound Hs Inhibitor Inhibition 8.2 pIC50 - 5
⤷ pIC50 8.2 (IC50 5.7x10-9 M) [5]
fms related receptor tyrosine kinase 3 Hs Inhibitor Inhibition 8.2 pIC50 - 4
⤷ pIC50 8.2 (IC50 6.5x10-9 M) [4]
fms related receptor tyrosine kinase 4 Primary target of this compound Hs Inhibitor Inhibition 8.1 pIC50 - 4
⤷ pIC50 8.1 (IC50 8.9x10-9 M) [4]
KIT proto-oncogene, receptor tyrosine kinase Primary target of this compound Hs Inhibitor Inhibition 7.9 pIC50 - 4
⤷ pIC50 7.9 (IC50 1.31x10-8 M) [4]
kinase insert domain receptor Hs Inhibitor Inhibition 7.7 pIC50 - 4
⤷ pIC50 7.7 (IC50 2.26x10-8 M) [4]
Ligand mentioned in the following text fields
Type III RTKs: PDGFR, CSFR, Kit, FLT3 receptor family comments