OX-40 ligand

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Ligands
OX-40 ligand (Human)

GtoPdb Ligand ID: 5076

Synonyms: glycoprotein Gp34 | TXGP-1

Compound class: Endogenous peptide in human, mouse or rat

Comment: OX40L (CD252) is the ligand for tumor necrosis factor receptor superfamily, member 4 (TNFRSF4, a.k.a. OX40 or CD134). OX40 is a secondary co-stimulatory immune checkpoint molecule expressed on activated T cells (requiring CD28 co-stimulatory signal), and OX40L is expressed on activated dendritic cells. The OX40/OX40L pair is involved in late T-cell costimulatory signaling and both are transiently expressed following antigen recognition, and blocking OX40/OX40L is reported to prevent the development of disease in in vivo autoimmune and inflammatory disease models [4]. The OX40/OX40L pathway is being investigated for the development of novel anti-inflammatory therapeutics and anti-cancer drugs.
An antibody binding mouse OX40L

Species: Human

Bioactivity Comments
OX40L is overexpressed in B cells, T cells, and fibroblasts in fibrotic skin of patients with systemic sclerosis (SSc) [1]. The authors suggest that soluble OX40L represents a promising biomarker [3] predictive of worsening fibrosis in these patients. Their in vivo studies in mouse models of SSc indicate that antibody-driven blockade of OX40L protects against inflammatory skin, lung, and vessel fibrosis, and can induce regression of established dermal fibrosis. This mechanism is ineffective in preventing noninflammatory skin fibrosis in a mouse model. These studies used the mouse anti-OX40L monoclonal RM134L. Blockade of OX40L activity has also been reported to be effective against arthritis in mouse models of the disease [2].

Bioactivity Comments

OX40L is overexpressed in B cells, T cells, and fibroblasts in fibrotic skin of patients with systemic sclerosis (SSc) [1]. The authors suggest that soluble OX40L represents a promising biomarker [3] predictive of worsening fibrosis in these patients. Their in vivo studies in mouse models of SSc indicate that antibody-driven blockade of OX40L protects against inflammatory skin, lung, and vessel fibrosis, and can induce regression of established dermal fibrosis. This mechanism is ineffective in preventing noninflammatory skin fibrosis in a mouse model. These studies used the mouse anti-OX40L monoclonal RM134L. Blockade of OX40L activity has also been reported to be effective against arthritis in mouse models of the disease [2].

Natural/Endogenous Targets