IL-1α   

GtoPdb Ligand ID: 4973

Synonyms: hematopoietin-1 | interleukin-1 alpha
Comment: IL-1α is an IL-1 family cytokine.
Species: Human
Natural/Endogenous Targets
Target
Interleukin-1 receptor, type I
Selectivity at catalytic receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
Interleukin-1 receptor, type I Hs Agonist Agonist - - -
Other ligands which bind to or alter the activity of this ligand
Key to terms and symbols Click column headers to sort
Ligand Sp. Type Action Value Parameter Concentration range (M) Reference
lutikizumab Hs Antibody Binding 11.1 pKd - 2
pKd 11.1 (Kd 7.6x10-12 M) [2]
bermekimab Hs Antibody Binding 10.7 pKd - 3
pKd 10.7 (Kd 2x10-11 M) [3]
lutikizumab Monkey Antibody Binding 9.4 pKd - 2
pKd 9.4 (Kd 4.11x10-10 M) [2]
lutikizumab Hs Antibody Binding 11.2 pEC50 - 2
pEC50 11.2 (EC50 6.4x10-12 M) [2]
Targets where the ligand is described in the comment field
Target Comment