Natural/Endogenous Targets
Target Interleukin-1 receptor, type I

Selectivity at catalytic receptors
Key to terms and symbols		Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference Interleukin-1 receptor, type I Hs Agonist Agonist - - - ⤷

Other ligands which bind to or alter the activity of this ligand
Key to terms and symbols	Click column headers to sort
Ligand Sp. Type Action Value Parameter Concentration range (M) Reference lutikizumab Hs Antibody Binding 11.1 pKd - 2 ⤷ pKd 11.1 (Kd 7.6x10-12 M) [2] bermekimab Hs Antibody Binding 10.7 pKd - 3 ⤷ pKd 10.7 (Kd 2x10-11 M) [3] lutikizumab Monkey Antibody Binding 9.4 pKd - 2 ⤷ pKd 9.4 (Kd 4.11x10-10 M) [2] lutikizumab Hs Antibody Binding 11.2 pEC50 - 2 ⤷ pEC50 11.2 (EC50 6.4x10-12 M) [2]

Targets where the ligand is described in the comment field
Target	Comment
Interleukin-1 receptor, type II	Decoy receptor that binds IL-1α (IL1A, P01583), IL-1β (IL1B, P01584) and IL-1 receptor antagonist (IL1RN, P18510).