insulin-like growth factor 1   Click here for help

GtoPdb Ligand ID: 4971

Abbreviated name: IGF-1
Synonyms: CEP-151 | mechano growth factor (MGF) | myotrophin
Approved drug
insulin-like growth factor 1 is an approved drug (FDA (2005))
Compound class: Endogenous peptide in human, mouse or rat
Comment: The recombinant form of human IGF-1 is an approved drug, mecasermin.
Species: Human
IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: insulin-like growth factor 1

Bioactivity Comments
We have been unable to find publicly available affinity data for this drug at its proposed molecular target to substantiate its MMOA, and have therefore not tagged a primary drug target.
Natural/Endogenous Targets
Target
Insulin-like growth factor I receptor
Selectivity at catalytic receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
Insulin-like growth factor I receptor Ligand is endogenous in the given species Hs Agonist Agonist - - -
⤷
Other ligands which bind to or alter the activity of this ligand
Key to terms and symbols Click column headers to sort
Ligand Sp. Type Action Value Parameter Concentration range (M) Reference
dusigitumab Peptide Primary target of this compound Hs Antibody Binding 9.7 pKd - 1
⤷ pKd 9.7 (Kd 2.16x10-10 M) [1]