IFN-α1/13   Click here for help

GtoPdb Ligand ID: 4955

Synonyms: IFN-α1 | IFN-α13 | IFN-alpha 1/13 | interferon alpha-1/13 | interferon alpha-D
Immunopharmacology Ligand
Compound class: Endogenous peptide in human, mouse or rat
Comment: Interferon-αs are type I IFNs (includes IFNαs, IFN-β, IFN-ε, IFN-κ and IFN-ω). In humans, there are 13 different IFN-α genes , but only 12 functional human IFN-α proteins, since IFN-α1 and IFN-α13 have identical protein sequences despite being encoded by separate genes.
Species: Human
Natural/Endogenous Targets
Target
Interferon-α/β receptor
Selectivity at catalytic receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
Interferon-α/β receptor Ligand is endogenous in the given species Hs Agonist Agonist - - -
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Other ligands which bind to or alter the activity of this ligand
Key to terms and symbols Click column headers to sort
Ligand Sp. Type Action Value Parameter Concentration range (M) Reference
rontalizumab Peptide Hs Antibody Binding 9.1 pKd - 1
⤷ pKd 9.1 (Kd 8.3x10-10 M) [1]
sifalimumab Peptide Hs Antibody Binding 8.3 pEC50 - 2
⤷ pEC50 8.3 (EC50 4.6x10-9 M) [2]
Description: Inhibition of the antiproliferative effect of IFNA1 on Daudi cells in culture.