Synonyms: Adrucil® | Carac®
5-fluorouracil is an approved drug (FDA (1962))
Compound class:
Synthetic organic
Comment: Fluoroacil is the active metabolite of the prodrugs capecitabine and floxuridine.
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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Bioactivity Comments |
We have been unable to find publicly available bioactivity data for this drug at its proposed molecular target (thymidylate synthase) to substantiate its MMOA, and have therefore not tagged a primary drug target. |
Transporters Moving this Compound Across a Lipid Membrane | ||||||||
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Targets where the ligand is described in the comment field | |
Target | Comment |
dihydropyrimidine dehydrogenase | Dihydropyrimidine dehydrogenase is required for the first and rate-limiting step of pyrimidine catabolism. In addition to degrading pyrimidines, it also breaks down pyrimidine-based 5-fluorouracil, the anticancer cytostatic agent that is produced from chemotherapeutic prodrugs including capecitabine and tegafur. |