Synonyms: prostaglandin H2
Compound class:
Metabolite or derivative
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖View more information in the IUPHAR Pharmacology Education Project: prostaglandin h2 |
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Enzymes Catalysing Reactions with this Compound as a Substrate or Product | ||||||||||||||||||||||||||||||||||||
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Additional information and targets (data relate to human unless otherwise stated) | ||
Description | Data | Reference |
Potency order of endogenous ligands at TP receptor | thromboxane A2 = PGH2 >> PGD2, PGE2, PGF2α, PGI2 |
Targets where the ligand is described in the comment field | |
Target | Comment |
CYP8A1 in CYP5, CYP7 and CYP8 families CYP8A1 in Prostaglandin synthases |
Converts prostaglandin H2 (PGH2) to thromboxane A2 (thromboxane A2) [2]. |
CYP4F8 | Converts PGH2 to 19-hydroxyPGH2 [1] and 8,9-EET or 11,12-EET to 18-hydroxy-8,9-EET or 18-hydroxy-11,12-EET [3]. |
Ligand mentioned in the following text fields |
Cyclooxygenase overview |
Prostaglandin synthases overview |
Prostanoid receptors overview |