succinic acid   Click here for help

GtoPdb Ligand ID: 3637

Synonyms: succinate
PDB Ligand
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 3
Topological polar surface area 74.6
Molecular weight 118.03
XLogP -0.71
No. Lipinski's rules broken 0
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Canonical SMILES OC(=O)CCC(=O)O
Isomeric SMILES OC(=O)CCC(=O)O
InChI InChI=1S/C4H6O4/c5-3(6)1-2-4(7)8/h1-2H2,(H,5,6)(H,7,8)
Natural/Endogenous Targets
succinate receptor
Enzymes Catalysing Reactions with this Compound as a Substrate or Product
Enzyme EC number Reaction Reference
aldehyde dehydrogenase 5 family member A1
Transporters Moving this Compound Across a Lipid Membrane
Transporter EC number Reaction Reference
Na+/dicarboxylate cotransporter 1
Na+/dicarboxylate cotransporter 3
Mitochondrial dicarboxylate transporter
Selectivity at GPCRs
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
succinate receptor Ligand is endogenous in the given species Hs Agonist Full agonist 3.1 – 4.7 pEC50 - 1-2
pEC50 3.1 – 4.7 (EC50 9.1x10-5 – 2x10-5 M) [1-2]